Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development, strongly suppresses GBM formation. Mechanisticall...

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Detalhes bibliográficos
Publicado no:eLife
Main Authors: Blake, Sophia M, Stricker, Stefan H, Halavach, Hanna, Poetsch, Anna R, Cresswell, George, Kelly, Gavin, Kanu, Nnennaya, Marino, Silvia, Luscombe, Nicholas M, Pollard, Steven M, Behrens, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: eLife Sciences Publications, Ltd 2016
Assuntos:
Cancer Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811777/
https://ncbi.nlm.nih.gov/pubmed/26984279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08711
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