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UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function

The Mre11/Rad50/NBS1 (MRN) protein complex and ATMIN protein mediate ATM kinase signaling in response to ionizing radiation (IR) and chromatin changes, respectively. NBS1 and ATMIN directly compete for ATM binding, but the molecular mechanism favoring either NBS1 or ATMIN in response to specific sti...

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Detalhes bibliográficos
Main Authors: Zhang, Tianyi, Cronshaw, Janet, Kanu, Nnennaya, Snijders, Ambrosius P., Behrens, Axel
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4143036/
https://ncbi.nlm.nih.gov/pubmed/25092319
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400230111
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