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UBR5-mediated ubiquitination of ATMIN is required for ionizing radiation-induced ATM signaling and function
The Mre11/Rad50/NBS1 (MRN) protein complex and ATMIN protein mediate ATM kinase signaling in response to ionizing radiation (IR) and chromatin changes, respectively. NBS1 and ATMIN directly compete for ATM binding, but the molecular mechanism favoring either NBS1 or ATMIN in response to specific sti...
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| Главные авторы: | , , , , |
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| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
National Academy of Sciences
2014
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4143036/ https://ncbi.nlm.nih.gov/pubmed/25092319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1400230111 |
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