Wordt geladen...

Inactivation of the ATMIN/ATM pathway protects against glioblastoma formation

Glioblastoma multiforme (GBM) is the most aggressive human primary brain cancer. Using a Trp53-deficient mouse model of GBM, we show that genetic inactivation of the Atm cofactor Atmin, which is dispensable for embryonic and adult neural development, strongly suppresses GBM formation. Mechanisticall...

Volledige beschrijving

Bewaard in:
Bibliografische gegevens
Gepubliceerd in:eLife
Hoofdauteurs: Blake, Sophia M, Stricker, Stefan H, Halavach, Hanna, Poetsch, Anna R, Cresswell, George, Kelly, Gavin, Kanu, Nnennaya, Marino, Silvia, Luscombe, Nicholas M, Pollard, Steven M, Behrens, Axel
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: eLife Sciences Publications, Ltd 2016
Onderwerpen:
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811777/
https://ncbi.nlm.nih.gov/pubmed/26984279
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.7554/eLife.08711
Tags: Voeg label toe
Geen labels, Wees de eerste die dit record labelt!