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The Role of Negative Selection in Protein Evolution Revealed through the Energetics of the Native State Ensemble
Knowing the determinants of conformational specificity is essential for understanding protein structure, stability, and fold evolution. To address this issue, a novel statistical measure of energetic compatibility between sequence and structure was developed, using an experimentally validated model...
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| Опубликовано в: : | Proteins |
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| Главные авторы: | , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4811355/ https://ncbi.nlm.nih.gov/pubmed/26800099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24989 |
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