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The Role of Negative Selection in Protein Evolution Revealed through the Energetics of the Native State Ensemble

Knowing the determinants of conformational specificity is essential for understanding protein structure, stability, and fold evolution. To address this issue, a novel statistical measure of energetic compatibility between sequence and structure was developed, using an experimentally validated model...

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Foilsithe in:Proteins
Main Authors: Hoffmann, Jordan, Wrabl, James O., Hilser, Vincent J.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2016
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811355/
https://ncbi.nlm.nih.gov/pubmed/26800099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24989
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