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The Role of Negative Selection in Protein Evolution Revealed through the Energetics of the Native State Ensemble

Knowing the determinants of conformational specificity is essential for understanding protein structure, stability, and fold evolution. To address this issue, a novel statistical measure of energetic compatibility between sequence and structure was developed, using an experimentally validated model...

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Dettagli Bibliografici
Pubblicato in:Proteins
Autori principali: Hoffmann, Jordan, Wrabl, James O., Hilser, Vincent J.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2016
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4811355/
https://ncbi.nlm.nih.gov/pubmed/26800099
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/prot.24989
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