Infection-dependent phenotypes in MHC-congenic mice are not due to MHC: can we trust congenic animals?

BACKGROUND: Congenic strains of mice are assumed to differ only at a single gene or region of the genome. These mice have great importance in evaluating the function of genes. However, their utility depends on the maintenance of this true congenic nature. Although, accumulating evidence suggests tha...

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Main Authors: McClelland, Erin E, Damjanovich, Kristy, Gardner, Kyle, Groesbeck, Zack J, Ma, Maggie S, Nibley, Megan, Richardson, Kelly S, Wilkinson, Maureen, Morrison, Linda C, Bernhardt, Paul, Potts, Wayne K
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2004
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC481063/
https://ncbi.nlm.nih.gov/pubmed/15245582
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2172-5-14
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