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Major Histocompatibility Complex Heterozygosity Reduces Fitness in Experimentally Infected Mice
It is often suggested that heterozygosity at major histocompatibility complex (MHC) loci confers enhanced resistance to infectious diseases (heterozygote advantage, HA, hypothesis), and overdominant selection should contribute to the evolution of these highly polymorphic genes. The evidence for the...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Copyright © 2007 by the Genetics Society of America
2007
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1950649/ https://ncbi.nlm.nih.gov/pubmed/17603099 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.107.074815 |
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