Impact of Heparan Sulfate Binding on Transduction of Retina by Recombinant Adeno-Associated Virus Vectors

Adeno-associated viruses (AAVs) currently are being developed to efficiently transduce the retina following noninvasive, intravitreal (Ivt) injection. However, a major barrier encountered by intravitreally delivered AAVs is the inner limiting membrane (ILM), a basement membrane rich in heparan sulfa...

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Bibliographic Details
Published in:J Virol
Main Authors: Boye, Sanford L., Bennett, Antonette, Scalabrino, Miranda L., McCullough, K. Tyler, Van Vliet, Kim, Choudhury, Shreyasi, Ruan, Qing, Peterson, James, Agbandje-McKenna, Mavis, Boye, Shannon E.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2016
Subjects:
Gene Delivery
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810560/
https://ncbi.nlm.nih.gov/pubmed/26865709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00200-16
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