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Valpromide Inhibits Lytic Cycle Reactivation of Epstein-Barr Virus

Reactivation of Epstein-Barr virus (EBV) from latency into the lytic phase of its life cycle allows the virus to spread among cells and between hosts. Valproic acid (VPA) inhibits initiation of the lytic cycle in EBV-infected B lymphoma cells. While VPA blocks viral lytic gene expression, it induces...

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Publicat a:mBio
Autors principals: Gorres, Kelly L., Daigle, Derek, Mohanram, Sudharshan, McInerney, Grace E., Lyons, Danielle E., Miller, George
Format: Artigo
Idioma:Inglês
Publicat: American Society of Microbiology 2016
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4810481/
https://ncbi.nlm.nih.gov/pubmed/26933051
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mBio.00113-16
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