Valproic Acid Antagonizes the Capacity of Other Histone Deacetylase Inhibitors To Activate the Epstein-Barr Virus Lytic Cycle

Diverse stimuli reactivate the Epstein-Barr virus (EBV) lytic cycle in Burkitt lymphoma (BL) cells. In HH514-16 BL cells, two histone deacetylase (HDAC) inhibitors, sodium butyrate (NaB) and trichostatin A (TSA), and the DNA methyltransferase inhibitor azacytidine (AzaCdR) promote lytic reactivation...

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Detalhes bibliográficos
Main Authors: Daigle, Derek, Gradoville, Lyn, Tuck, David, Schulz, Vince, Wang'ondu, Ruth, Ye, Jianjiang, Gorres, Kelly, Miller, George
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2011
Assuntos:
Genome Replication and Regulation of Viral Gene Expression
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3094991/
https://ncbi.nlm.nih.gov/pubmed/21411522
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02659-10
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