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Absorption of riociguat (BAY 63-2521): bioavailability, food effects, and dose proportionality
Abstract. Riociguat (BAY 63-2521) is the first member of a novel class of compounds, the soluble guanylate cyclase (sGC) stimulators. Riociguat has a dual mode of action: it sensitizes sGC to endogenous nitric oxide (NO) and stimulates sGC independent of NO availability. To characterize the biopharm...
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| 發表在: | Pulm Circ |
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| Main Authors: | , , , , , |
| 格式: | Artigo |
| 語言: | Inglês |
| 出版: |
University of Chicago Press
2016
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| 主題: | |
| 在線閱讀: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4809663/ https://ncbi.nlm.nih.gov/pubmed/27096084 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/685018 |
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