Assessment of the effects of renal impairment and smoking on the pharmacokinetics of a single oral dose of the soluble guanylate cyclase stimulator riociguat (BAY 63-2521)

Abstract. Renal impairment is a common comborbidity in patients with pulmonary hypertension. The breakdown of riociguat, an oral soluble guanylate cyclase stimulator used to treat pulmonary hypertension, may be affected by smoking because polycyclic aromatic hydrocarbons in tobacco smoke induce expr...

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Publicat a:Pulm Circ
Autors principals: Frey, Reiner, Becker, Corina, Unger, Sigrun, Schmidt, Anja, Wensing, Georg, Mück, Wolfgang
Format: Artigo
Idioma:Inglês
Publicat: University of Chicago Press 2016
Matèries:
Original Research
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4860531/
https://ncbi.nlm.nih.gov/pubmed/27162624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/685017
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