Absorption of riociguat (BAY 63-2521): bioavailability, food effects, and dose proportionality

Abstract. Riociguat (BAY 63-2521) is the first member of a novel class of compounds, the soluble guanylate cyclase (sGC) stimulators. Riociguat has a dual mode of action: it sensitizes sGC to endogenous nitric oxide (NO) and stimulates sGC independent of NO availability. To characterize the biopharm...

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Библиографические подробности
Опубликовано в: :Pulm Circ
Главные авторы: Becker, Corina, Frey, Reiner, Hesse, Christiane, Unger, Sigrun, Reber, Michael, Mück, Wolfgang
Формат: Artigo
Язык:Inglês
Опубликовано: University of Chicago Press 2016
Предметы:
Original Research
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809663/
https://ncbi.nlm.nih.gov/pubmed/27096084
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/685018
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