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Bayesian Group Sequential Clinical Trial Design using Total Toxicity Burden and Progression-Free Survival

Delivering radiation to eradicate a solid tumor while minimizing damage to nearby critical organs remains a challenge. For esophageal cancer, radiation therapy may damage the heart or lungs, and several qualitatively different, possibly recurrent toxicities associated with chemoradiation or surgery...

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Detalhes bibliográficos
Publicado no:J R Stat Soc Ser C Appl Stat
Main Authors: Hobbs, Brian P., Thall, Peter F., Lin, Steven H.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809549/
https://ncbi.nlm.nih.gov/pubmed/27034510
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/rssc.12117
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