Ubiquitin-specific protease 22 is a deubiquitinase of CCNB1

The elevated level of CCNB1 indicates more aggressive cancer and poor prognosis. However, the factors that cause CCNB1 upregulation remain enigmatic. Herein, we identify USP22 as a CCNB1 interactor and discover that both USP22 and CCNB1 are dramatically elevated with a strong positive correlation in...

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Veröffentlicht in:Cell Discov
Hauptverfasser: Lin, Zhenghong, Tan, Can, Qiu, Quan, Kong, Sinyi, Yang, Heeyoung, Zhao, Fang, Liu, Zhaojian, Li, Jinping, Kong, Qingfei, Gao, Beixue, Barrett, Terry, Yang, Guang-Yu, Zhang, Jianing, Fang, Deyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809424/
https://ncbi.nlm.nih.gov/pubmed/27030811
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/celldisc.2015.28
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