USP10 Antagonizes c-Myc Transcriptional Activation through SIRT6 Stabilization to Suppress Tumor Formation

The reduced protein expression of SIRT6 tumor suppressor is involved in tumorigenesis. The molecular mechanisms underlying SIRT6 protein downregulation in human cancers remain unknown. Using a proteomic approach, we have identified the ubiquitin-specific peptidase USP10, another tumor suppressor, as...

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Hlavní autoři: Lin, Zhenghong, Yang, Heeyoung, Tan, Can, Li, Jinping, Liu, Zhaojian, Quan, Qiu, Kong, Sinyi, Ye, Junsheng, Gao, Beixue, Fang, Deyu
Médium: Artigo
Jazyk:Inglês
Vydáno: 2013
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4007576/
https://ncbi.nlm.nih.gov/pubmed/24332849
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2013.11.029
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