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Organometallic Palladium Reagents for Cysteine Bioconjugation

Transition-metal based reactions have found wide use in organic synthesis and are used frequently to functionalize small molecules.(1,2) However, there are very few reports of using transition-metal based reactions to modify complex biomolecules(3,4), which is due to the need for stringent reaction...

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Pubblicato in:Nature
Autori principali: Vinogradova, Ekaterina V., Zhang, Chi, Spokoyny, Alexander M., Pentelute, Bradley L., Buchwald, Stephen L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2015
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809359/
https://ncbi.nlm.nih.gov/pubmed/26511579
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature15739
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