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T cell help controls the speed of the cell cycle in germinal center B cells

The germinal center (GC) is a microanatomical compartment wherein high affinity antibody-producing B cells are selectively expanded. B cells proliferate and mutate their antibody genes in the dark zone (DZ) of the GC, and are then selected by T cells in the light zone (LZ) on the basis of affinity....

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Publicado en:Science
Autores principales: Gitlin, Alexander D., Mayer, Christian T., Oliveira, Thiago Y., Shulman, Ziv, Jones, Mathew J.K., Koren, Amnon, Nussenzweig, Michel C.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2015
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4809261/
https://ncbi.nlm.nih.gov/pubmed/26184917
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aac4919
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