Phospholipase D Elevates the Level of MDM2 and Suppresses DNA Damage-Induced Increases in p53

Phospholipase D (PLD) has been reported to generate survival signals that prevent apoptosis induced by serum withdrawal. We have now found that elevated expression of PLD also suppresses DNA damage-induced apoptosis. Since DNA damage-induced apoptosis is often mediated by p53, we examined the effect...

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Main Authors: Hui, Li, Abbas, Tarek, Pielak, Rafal M., Joseph, Troy, Bargonetti, Jill, Foster, David A.
Formato: Artigo
Idioma:Inglês
Publicado: American Society for Microbiology 2004
Assuntos:
Cell Growth and Development
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC480910/
https://ncbi.nlm.nih.gov/pubmed/15199126
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5677-5686.2004
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