Mice Deficient for All PIM Kinases Display Reduced Body Size and Impaired Responses to Hematopoietic Growth Factors

The Pim family of proto-oncogenes encodes a distinct class of serine/threonine kinases consisting of PIM1, PIM2, and PIM3. Although the Pim genes are evolutionarily highly conserved, the contribution of PIM proteins to mammalian development is unclear. PIM1-deficient mice were previously described b...

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Detalhes bibliográficos
Main Authors: Mikkers, Harald, Nawijn, Martijn, Allen, John, Brouwers, Conny, Verhoeven, Els, Jonkers, Jos, Berns, Anton
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mammalian Genetic Models with Minimal or Complex Phenotypes
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC480904/
https://ncbi.nlm.nih.gov/pubmed/15199164
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.6104-6115.2004
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