Frat is dispensable for canonical Wnt signaling in mammals

Wnt-signal transduction through β-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active W...

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Dades bibliogràfiques
Autors principals: van Amerongen, Renée, Nawijn, Martijn, Franca-Koh, Jonathan, Zevenhoven, John, van der Gulden, Hanneke, Jonkers, Jos, Berns, Anton
Format: Artigo
Idioma:Inglês
Publicat: Cold Spring Harbor Laboratory Press 2005
Matèries:
Research Communications
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC548942/
https://ncbi.nlm.nih.gov/pubmed/15681612
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.326705
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