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Frat is dispensable for canonical Wnt signaling in mammals
Wnt-signal transduction through β-catenin is thought to require the inhibition of GSK3 by Frat/GBP. To investigate the role of Frat in mammalian development, we have generated mice with targeted mutations in all three murine Frat homologs. We show that Frat is normally expressed at sites of active W...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Cold Spring Harbor Laboratory Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC548942/ https://ncbi.nlm.nih.gov/pubmed/15681612 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1101/gad.326705 |
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