Amplification of Mdmx (or Mdm4) Directly Contributes to Tumor Formation by Inhibiting p53 Tumor Suppressor Activity

Human tumors are believed to harbor a disabled p53 tumor suppressor pathway, either through direct mutation of the p53 gene or through aberrant expression of proteins acting in the p53 pathway, such as p14(ARF) or Mdm2. A role for Mdmx (or Mdm4) as a key negative regulator of p53 function in vivo ha...

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Hauptverfasser: Danovi, Davide, Meulmeester, Erik, Pasini, Diego, Migliorini, Domenico, Capra, Maria, Frenk, Ruth, de Graaf, Petra, Francoz, Sarah, Gasparini, Patrizia, Gobbi, Alberto, Helin, Kristian, Pelicci, Pier Giuseppe, Jochemsen, Aart G., Marine, Jean-Christophe
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2004
Schlagworte:
Cell Growth and Development
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC480894/
https://ncbi.nlm.nih.gov/pubmed/15199139
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.24.13.5835-5843.2004
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