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Macrophage IKKalpha deficiency suppresses Akt phosphorylation, reduces cell survival and decreases early atherosclerosis
OBJECTIVE: The IκB kinase (IKK) is an enzyme complex that initiates the NF-κB transcription factor cascade, which is important in regulating multiple cellular responses. IKK alpha (IKKα) is directly associated with two major pro-survival pathways, PI3K/Akt and NF-κB, but its role in cell survival is...
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| Опубликовано в: : | Arterioscler Thromb Vasc Biol |
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| Главные авторы: | , , , , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4808396/ https://ncbi.nlm.nih.gov/pubmed/26848161 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/ATVBAHA.115.306931 |
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