RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

AGEs accumulation in the skin affects extracellular matrix (ECM) turnover and triggers diabetes associated skin conditions and accelerated skin aging. The receptor of AGEs (RAGE) has an essential contribution to cellular dysfunction driven by chronic inflammatory responses while TGF-β1 is critical i...

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Veröffentlicht in:PLoS One
Hauptverfasser: Serban, Andreea Iren, Stanca, Loredana, Geicu, Ovidiu Ionut, Munteanu, Maria Cristina, Dinischiotu, Anca
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807770/
https://ncbi.nlm.nih.gov/pubmed/27015414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152376
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