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RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

AGEs accumulation in the skin affects extracellular matrix (ECM) turnover and triggers diabetes associated skin conditions and accelerated skin aging. The receptor of AGEs (RAGE) has an essential contribution to cellular dysfunction driven by chronic inflammatory responses while TGF-β1 is critical i...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Serban, Andreea Iren, Stanca, Loredana, Geicu, Ovidiu Ionut, Munteanu, Maria Cristina, Dinischiotu, Anca
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807770/
https://ncbi.nlm.nih.gov/pubmed/27015414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152376
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