RAGE and TGF-β1 Cross-Talk Regulate Extracellular Matrix Turnover and Cytokine Synthesis in AGEs Exposed Fibroblast Cells

AGEs accumulation in the skin affects extracellular matrix (ECM) turnover and triggers diabetes associated skin conditions and accelerated skin aging. The receptor of AGEs (RAGE) has an essential contribution to cellular dysfunction driven by chronic inflammatory responses while TGF-β1 is critical i...

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Vydáno v:PLoS One
Hlavní autoři: Serban, Andreea Iren, Stanca, Loredana, Geicu, Ovidiu Ionut, Munteanu, Maria Cristina, Dinischiotu, Anca
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2016
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807770/
https://ncbi.nlm.nih.gov/pubmed/27015414
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0152376
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