Anabolic and Antiresorptive Modulation of Bone Homeostasis by the Epigenetic Modulator Sulforaphane, a Naturally Occurring Isothiocyanate

Bone degenerative pathologies like osteoporosis may be initiated by age-related shifts in anabolic and catabolic responses that control bone homeostasis. Here we show that sulforaphane (SFN), a naturally occurring isothiocyanate, promotes osteoblast differentiation by epigenetic mechanisms. SFN enha...

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Vydáno v:J Biol Chem
Hlavní autoři: Thaler, Roman, Maurizi, Antonio, Roschger, Paul, Sturmlechner, Ines, Khani, Farzaneh, Spitzer, Silvia, Rumpler, Monika, Zwerina, Jochen, Karlic, Heidrun, Dudakovic, Amel, Klaushofer, Klaus, Teti, Anna, Rucci, Nadia, Varga, Franz, van Wijnen, Andre J.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Cell Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807263/
https://ncbi.nlm.nih.gov/pubmed/26757819
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.678235
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