Conserved Amphipathic Helices Mediate Lipid Droplet Targeting of Perilipins 1–3

Perilipins (PLINs) play a key role in energy storage by orchestrating the activity of lipases on the surface of lipid droplets. Failure of this activity results in severe metabolic disease in humans. Unlike all other lipid droplet-associated proteins, PLINs localize almost exclusively to the phospho...

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Vydáno v:J Biol Chem
Hlavní autoři: Rowe, Emily R., Mimmack, Michael L., Barbosa, Antonio D., Haider, Afreen, Isaac, Iona, Ouberai, Myriam M., Thiam, Abdou Rachid, Patel, Satish, Saudek, Vladimir, Siniossoglou, Symeon, Savage, David B.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2016
Témata:
Membrane Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807253/
https://ncbi.nlm.nih.gov/pubmed/26742848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.691048
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