Activation of Transmembrane Bile Acid Receptor TGR5 Modulates Pancreatic Islet α Cells to Promote Glucose Homeostasis

The physiological role of the TGR5 receptor in the pancreas is not fully understood. We previously showed that activation of TGR5 in pancreatic β cells by bile acids induces insulin secretion. Glucagon released from pancreatic α cells and glucagon-like peptide 1 (GLP-1) released from intestinal L ce...

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Bibliographic Details
Published in:J Biol Chem
Main Authors: Kumar, Divya P., Asgharpour, Amon, Mirshahi, Faridoddin, Park, So Hyun, Liu, Sichen, Imai, Yumi, Nadler, Jerry L., Grider, John R., Murthy, Karnam S., Sanyal, Arun J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2016
Subjects:
Metabolism
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807250/
https://ncbi.nlm.nih.gov/pubmed/26757816
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.699504
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