Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases

Bruton’s tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec kinases are allosterically activated by the adjace...

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Bibliographic Details
Published in:PLoS Comput Biol
Main Authors: Chopra, Nikita, Wales, Thomas E., Joseph, Raji E., Boyken, Scott E., Engen, John R., Jernigan, Robert L., Andreotti, Amy H.
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4807093/
https://ncbi.nlm.nih.gov/pubmed/27010561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004826
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