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Dynamic Allostery Mediated by a Conserved Tryptophan in the Tec Family Kinases
Bruton’s tyrosine kinase (Btk) is a Tec family non-receptor tyrosine kinase that plays a critical role in immune signaling and is associated with the immunological disorder X-linked agammaglobulinemia (XLA). Our previous findings showed that the Tec kinases are allosterically activated by the adjace...
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| Veröffentlicht in: | PLoS Comput Biol |
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| Hauptverfasser: | , , , , , , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Public Library of Science
2016
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4807093/ https://ncbi.nlm.nih.gov/pubmed/27010561 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pcbi.1004826 |
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