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Caspase-2 resides in the mitochondria and mediates apoptosis directly from the mitochondrial compartment

Caspase-2 plays an important role in apoptosis induced by several stimuli, including oxidative stress. However, the subcellular localization of caspase-2, particularly its presence in the mitochondria, is unclear. It is also not known if cytosolic caspase-2 translocates to the mitochondria to trigge...

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Detalhes bibliográficos
Publicado no:Cell Death Discov
Main Authors: Lopez-Cruzan, M, Sharma, R, Tiwari, M, Karbach, S, Holstein, D, Martin, C R, Lechleiter, J D, Herman, B
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4806400/
https://ncbi.nlm.nih.gov/pubmed/27019748
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/cddiscovery.2016.5
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