Spectroscopic and Theoretical Study of Cu(I) Binding to His111 in the Human Prion Protein Fragment 106–115

[Image: see text] The ability of the cellular prion protein (PrP(C)) to bind copper in vivo points to a physiological role for PrP(C) in copper transport. Six copper binding sites have been identified in the nonstructured N-terminal region of human PrP(C). Among these sites, the His111 site is uniqu...

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Udgivet i:Inorg Chem
Main Authors: Arcos-López, Trinidad, Qayyum, Munzarin, Rivillas-Acevedo, Lina, Miotto, Marco C., Grande-Aztatzi, Rafael, Fernández, Claudio O., Hedman, Britt, Hodgson, Keith O., Vela, Alberto, Solomon, Edward I., Quintanar, Liliana
Format: Artigo
Sprog:Inglês
Udgivet: American Chemical Society 2016
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804749/
https://ncbi.nlm.nih.gov/pubmed/26930130
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.inorgchem.5b02794
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