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Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes
Protein aggregation and particle formation have been observed when protein solutions contact hydrophobic interfaces, and it has been suggested that this undesirable phenomenon may be initiated by interfacial adsorption and subsequent gelation of the protein. The addition of surfactants, such as poly...
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| Pubblicato in: | J Pharm Sci |
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| Autori principali: | , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4804708/ https://ncbi.nlm.nih.gov/pubmed/26413998 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24654 |
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