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In Vivo Analysis of the Potency of Silicone Oil Microdroplets as Immunological Adjuvants in Protein Formulations

Subvisible particles in a therapeutic protein product may act as adjuvants to promote unwanted immune responses against the protein. Silicone oil is used as a lubricant in prefilled syringes, and microdroplets of silicone oil are often detected in protein formulations expelled from prefilled syringe...

תיאור מלא

שמור ב:
מידע ביבליוגרפי
הוצא לאור ב:J Pharm Sci
Main Authors: Chisholm, Carly Fleagle, Nguyen, Bao Han, Soucie, Kaitlin R., Torres, Raul M., Carpenter, John F., Randolph, Theodore W.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2015
נושאים:
גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4604024/
https://ncbi.nlm.nih.gov/pubmed/26190624
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24573
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