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Silicone Oil Microdroplets Can Induce Antibody Responses Against Recombinant Murine Growth Hormone In Mice

Therapeutic protein products can cause adverse immune responses in patients. The presence of sub-visible particles is a potential contributing factor to the immunogenicity of parenterally-administered therapeutic protein formulations. Silicone oil microdroplets, which derive from silicone oil used a...

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Detalhes bibliográficos
Publicado no:J Pharm Sci
Main Authors: Chisholm, Carly Fleagle, Baker, Abby E., Soucie, Kaitlin R., Torres, Raul M., Carpenter, John F., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4846524/
https://ncbi.nlm.nih.gov/pubmed/27020987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2016.02.019
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