Recombinant Murine Growth Hormone Particles are More Immunogenic with Intravenous than Subcutaneous Administration

Evaluation and mitigation of the risk of immunogenicity to protein aggregates and particles in therapeutic protein products remains a primary concern for drug developers and regulatory agencies. In order to investigate how the presence of protein particles and the route of administration influence t...

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Bibliographic Details
Main Authors: Christie, Merry, Torres, Raul M., Kedl, Ross M., Randolph, Theodore W., Carpenter, John F.
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4137484/
https://ncbi.nlm.nih.gov/pubmed/25133276
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