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Flow microscopy imaging is sensitive to characteristics of subvisible particles in peginesatide formulations associated with severe adverse reactions
The presence of subvisible particles in formulations of therapeutic proteins is a risk factor for adverse immune responses. Although the immunogenic potential of particulate contaminants likely depends on particle structural characteristics (e.g., composition, size, and shape), exact structure-immun...
Guardat en:
| Publicat a: | J Pharm Sci |
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| Autors principals: | , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2018
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916335/ https://ncbi.nlm.nih.gov/pubmed/29409840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.01.015 |
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