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Flow microscopy imaging is sensitive to characteristics of subvisible particles in peginesatide formulations associated with severe adverse reactions
The presence of subvisible particles in formulations of therapeutic proteins is a risk factor for adverse immune responses. Although the immunogenic potential of particulate contaminants likely depends on particle structural characteristics (e.g., composition, size, and shape), exact structure-immun...
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| Опубликовано в: : | J Pharm Sci |
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| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2018
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5916335/ https://ncbi.nlm.nih.gov/pubmed/29409840 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.xphs.2018.01.015 |
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