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Machine Learning & Statistical Analyses for Extracting and Characterizing "Fingerprints" of Antibody Aggregation at Container Interfaces from Flow Microscopy Images

Therapeutic proteins are exposed to numerous stresses during their manufacture, shipping, storage and administration to patients, causing them to aggregate and form particles through a variety of different mechanisms. These varied mechanisms generate particle populations with characteristic morpholo...

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Detalhes bibliográficos
Publicado no:Biotechnol Bioeng
Main Authors: Daniels, Austin L., Calderon, Christopher P., Randolph, Theodore W.
Formato: Artigo
Idioma:Inglês
Publicado em: 2020
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7855730/
https://ncbi.nlm.nih.gov/pubmed/32667683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/bit.27501
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