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Surfactant Effects on Particle Generation in Antibody Formulations in Pre-filled Syringes

Protein aggregation and particle formation have been observed when protein solutions contact hydrophobic interfaces, and it has been suggested that this undesirable phenomenon may be initiated by interfacial adsorption and subsequent gelation of the protein. The addition of surfactants, such as poly...

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Foilsithe in:J Pharm Sci
Main Authors: Gerhardt, Alana, McUmber, Aaron C., Nguyen, Bao H., Lewus, Rachael, Schwartz, Daniel K., Carpenter, John F., Randolph, Theodore W.
Formáid: Artigo
Teanga:Inglês
Foilsithe: 2015
Ábhair:
Rochtain Ar Líne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4804708/
https://ncbi.nlm.nih.gov/pubmed/26413998
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jps.24654
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