ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models

BACKGROUND: Hypoxia-inducible factors (HIFs) are well-established mediators of tumor growth, the epithelial to mesenchymal transition (EMT) and metastasis. In several types of solid tumors, including breast cancers, the HIFs play a critical role in maintaining cancer stem cell (CSC) activity. Thus,...

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Detalhes bibliográficos
Publicado no:Mol Cancer
Main Authors: Brooks, Danielle L. Peacock, Schwab, Luciana P., Krutilina, Raisa, Parke, Deanna N., Sethuraman, Aarti, Hoogewijs, David, Schörg, Alexandra, Gotwald, Lauren, Fan, Meiyun, Wenger, Roland H., Seagroves, Tiffany N.
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802728/
https://ncbi.nlm.nih.gov/pubmed/27001172
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12943-016-0510-x
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