Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis

Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservation of miR-122 in the TGFβ pathway: miR-122 target site is present in the mouse but not hum...

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Udgivet i:Nat Commun
Main Authors: Yin, Shenyi, Fan, Yu, Zhang, Hanshuo, Zhao, Zhihua, Hao, Yang, Li, Juan, Sun, Changhong, Yang, Junyu, Yang, Zhenjun, Yang, Xiao, Lu, Jian, Xi, Jianzhong Jeff
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4802055/
https://ncbi.nlm.nih.gov/pubmed/26987776
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11012
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