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A Magnetic Bead-Integrated Chip for the Large Scale Manufacture of Normalized esiRNAs

The chemically-synthesized siRNA duplex has become a powerful and widely used tool for RNAi loss-of-function studies, but suffers from a high off-target effect problem. Recently, endoribonulease-prepared siRNA (esiRNA) has been shown to be an attractive alternative due to its lower off-target effect...

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Main Authors: Wang, Zhao, Huang, Huang, Zhang, Hanshuo, Sun, Changhong, Hao, Yang, Yang, Junyu, Fan, Yu, Xi, Jianzhong Jeff
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2012
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3384639/
https://ncbi.nlm.nih.gov/pubmed/22761791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0039419
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