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Differential TGFβ pathway targeting by miR-122 in humans and mice affects liver cancer metastasis
Downregulation of a predominantly hepatocyte-specific miR-122 is associated with human liver cancer metastasis, whereas miR-122-deficient mice display normal liver function. Here we show a functional conservation of miR-122 in the TGFβ pathway: miR-122 target site is present in the mouse but not hum...
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| Publicado no: | Nat Commun |
|---|---|
| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4802055/ https://ncbi.nlm.nih.gov/pubmed/26987776 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms11012 |
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