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Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems

Cyclophilins catalyze cis ↔ trans isomerization of peptidyl–prolyl bonds, influencing protein folding along with a breadth of other biological functions such as signal transduction. Here, we have determined the microscopic rate constants defining the full enzymatic cycle for three human cyclophilins...

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Bibliografski detalji
Izdano u:Biochemistry
Glavni autori: Holliday, Michael J., Armstrong, Geoffrey S., Eisenmesser, Elan Z.
Format: Artigo
Jezik:Inglês
Izdano: 2015
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4801485/
https://ncbi.nlm.nih.gov/pubmed/26335054
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00746
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