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Catalysis of cis/trans isomerization in native HIV-1 capsid by human cyclophilin A

Packaging of cyclophilin A (CypA) into HIV-1 virions is essential for efficient replication; however, the reason for this is unknown. Incorporation is mediated through binding to the Gly-89–Pro-90 peptide bond of the N-terminal domain of HIV-1 capsid (CA(N)). Despite the fact that CypA is a peptidyl...

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Detalhes bibliográficos
Main Authors: Bosco, Daryl A., Eisenmesser, Elan Z., Pochapsky, Susan, Sundquist, Wesley I., Kern, Dorothee
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2002
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC122755/
https://ncbi.nlm.nih.gov/pubmed/11929983
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.082100499
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