Cyclophilin A catalyzes proline isomerization by an electrostatic handle mechanism

Proline isomerization is a ubiquitous process that plays a key role in the folding of proteins and in the regulation of their functions. Different families of enzymes, known as “peptidyl-prolyl isomerases” (PPIases), catalyze this reaction, which involves the interconversion between the cis and tran...

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Главные авторы: Camilloni, Carlo, Sahakyan, Aleksandr B., Holliday, Michael J., Isern, Nancy G., Zhang, Fengli, Eisenmesser, Elan Z., Vendruscolo, Michele
Формат: Artigo
Язык:Inglês
Опубликовано: National Academy of Sciences 2014
Предметы:
Biological Sciences
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4104850/
https://ncbi.nlm.nih.gov/pubmed/24982184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1404220111
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