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Determination of the Full Catalytic Cycle among Multiple Cyclophilin Family Members and Limitations on the Application of CPMG-RD in Reversible Catalytic Systems
Cyclophilins catalyze cis ↔ trans isomerization of peptidyl–prolyl bonds, influencing protein folding along with a breadth of other biological functions such as signal transduction. Here, we have determined the microscopic rate constants defining the full enzymatic cycle for three human cyclophilins...
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| Pubblicato in: | Biochemistry |
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| Autori principali: | , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
2015
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4801485/ https://ncbi.nlm.nih.gov/pubmed/26335054 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.biochem.5b00746 |
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